Unless you have been sleeping rather a lot recently, you may be aware that the Kama Sutra Worm/Virus hits tomorrow (and indeed any other 3rd day of the month). Kama (or Karma) Sutra, or Nyxem-D or Blackworm is comparatively rare among viruses and worms in that it is simply destructive - there doesn't seem to be any other purpose to it at all.

Generally if you have up to date virus software, it should be identified and trapped before it causes any problems. If you have email virus scanning software on your network border, even better.

If not, make sure you have a valid backup, and be prepared for a long day tomorrow.